In Isolation, the "Don't Get Stranded" game, the board is a 6x8 grid of removable squares. On your turn, you move your pawn one space, then remove a square. The object is isolate the opponent so they cannot move.
This game is one of a series of 2 player strategy games by Lakeside from the 1970s, also including Overboard, Trespass and Blockade. And it's also one of Ravensburger's Traveller-Series games.
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